Scientists have turned breast cancer cells into fat cells in a proof-of-concept study done on mice, according to Science Alert. Researchers for the study took mice that were implanted with an aggressive form of human breast cancer and treated them with two drugs meant for diabetic treatment and cancer treatment. The combination of the two drugs prevented the spreading of cancer cells, and instead, turned those cancer cells into fat cells in a process called adipogenesis.
“The given results indicate that in a patient-relevant setting combined therapy with rosiglitazone and trametinib specifically targets cancer cells with increased plasticity and induces their adipogenesis,” wrote research team members on their findings. “The breast cancer cells that underwent an EMT not only differentiated into fat cells but also completely stopped proliferating,” stated senior author Gerhard Christofori, a biochemist at the University of Basel, in Switzerland.